In postmenopausal women, taking tamoxifen slows down bone loss and can reduce the risk of osteoporosis. However, your risk may be higher if you’re 45 or under and your periods have stopped for at least a year. This is unlikely to lead to osteoporosis, unless ovarian suppression is given as well. Tamoxifen may slightly increase the risk of osteoporosis for premenopausal women. Tamoxifen blocks the effect of oestrogen on cancer cells. However, having less oestrogen in the body can also reduce bone density. This means there is less oestrogen in the body to help the cancer to grow. Ovarian suppression is when the ovaries are stopped from working (suppressed), either temporarily or permanently. Some research has shown that postmenopausal women who have chemotherapy may have greater loss of bone density than they would have had without chemotherapy. Women aged 45 or under whose periods have stopped for at least a year as a result of treatment may also be at risk of osteoporosis, even if their periods restart. This means less oestrogen is produced, which can reduce bone density.
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